Learning Objectives:

1. to construct a relevant clinical question regarding therapy for a specific problem.
2. to understand validity criteria for therapy
3. to understand relative risk reduction, absolute risk reduction, and number needed to treat (NNT)
4. to apply results to a patient scenario

• Therapy Lecture slides

• Symplicity HTN-2 Investigators, Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Böhm M. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010 Dec 4;376(9756):1903-9. Epub 2010 Nov 17. PubMed PMID: 21093036.

• FRISBE - Expanded Critical Appraisal Worksheet with Key Learning Points (PDF)

• Additional information on calculating ARR, RRR, and NNT

• Cheat Sheet for ARR, RRR,and NNT

• PICO worksheet (PDF)

• JAMAevidence: Therapy (Randomized Trials)

• How to Critically Appraise an Article About Therapy or Prevention