Duke University Medical Center Library Online - EBM: Finding Evidence for Harm Questions

Does treating children and adolescents for depression with SSRIs or antidepressants increase the risk for suicide or life threatening behavior?

MEDLINE (Ovid or PubMed)
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- Search text words and MeSH (medical subject headings)
- Limit to children or adolescents (using title words)
- Limit to best study design (RCT or cohort) or Clinical queries (consider Therapy/narrow or Etiology/narrow)

Check references within or at the end of journal articles or letters
Barbui C. Antidepressants and suicide symptoms: compelling new insights from the FDA's analysis of individual patient level data. Evid Based Ment Health. 2008 May;11(2):34-5. PubMed PMID: 18441126. See 1st reference: Laughren T. Briefing document for December 13 meeting of Psychopharmacologic Drugs Advisory Committee. Available at www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4272b1-index.htm (accessed 3 April 2007)
Whittington CJ, et al. Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data. Lancet. 2004 Apr 24;363(9418):1341-5. (See Committee on Safety of Medicines Report for Reference #17)
Lenzer J. Secret US report surfaces on antidepressants in children. BMJ. 2004 Aug 7;329(7461):307. (See reference to Alliance for Human Research Protection in first paragraph) Mosholder Report Feb 2004: Suicidality in Pediatric Clinical Trials
Developing Systematic Reviews for Comparative Effectiveness Research. Source for Pharma data and Grey Literature

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