Clinical Question:

Published:

• MEDLINE (Ovid or PubMed)
  • formulate question
  • textwords and MeSH (medical subject headings)
  • limiting to children or adolescents (using title words)
  • selecting the best study design (RCT or cohort)
  • Clinical queries

Unpublished:

• Published literature:
  • Check references within or at the end of journal articles or letters
    Whittington CJ, et al. Selective serotonin reuptake inhibitors in childhood depression: systematic review of published versus unpublished data. Lancet. 2004 Apr 24;363(9418):1341-5.

  • Lenzer J. Secret US report surfaces on antidepressants in children. BMJ. 2004 Aug 7;329(7461):307. (See reference to Alliance for Human Research Protection in first paragraph)
    Mosholder Report Feb 2004: Suicidality in Pediatric Clinical Trials

• Government Websites:
  • FDA
    FDA MedWatch - Safety Information
    FDA Dockets Management
    Antidepressant Use in Children, Adolescents, and Adults

  • National Institute of Mental Health: TADS Study

• Pharmaceutical companies:
  • GlaxoSmithKline: Paroxetine and pediatric and adolescent patients
    GlaxoSmithKline Clinical Trails Register

  • Eli Lilly and Company Clinical Trial Registry

• Web Sites:
  • ClinicalTrials.gov

  • Clinical Study Results (products approved since Oct 2002)

• PubMed:
  • Search for topic with textword - unpublish* or disclosure (MeSH)

• Google
  • Use the PICO format to search google: adolescent depression paroxetine suicide clinical data